Source Science
Published scientific context—including extracellular-vesicle research—and the relationship between researchers, institutions and papers.
SCIENCE
TRANSLATING SCIENCE WITH CARE
Scientific precision,
translated for skin
Scientific background, cosmetic ingredients and product design each carry a different meaning. We keep them distinct and present information that can be checked.
TWO FOUNDATIONS
From source science
to cosmetic ingredients
Research papers are the source of scientific insight; they do not by themselves prove the efficacy of a finished cosmetic. Finished-product results are presented separately on Evidence & Results.
Ingredient Translation
Nomenclature, quality review and registration information needed to translate research context into a cosmetic ingredient.
FROM ORGAN REGENERATION TO CONSUMER SCIENCE
From medical research
to everyday skincare
tiptop’s public Source Index connects organ-regeneration research, clinical development, regulatory records, ingredient development and manufacturing in Japan without confusing their owners or meanings. CELLshot is a cosmetic brand—not a medicine—and inherits this discipline of research and quality.
Nature → Science Translational Medicine
From lung-regeneration research published in Nature in 2015 to a 2024 Science Translational Medicine clinical study of autologous P63+ lung progenitor cells.
Nature / PMID 25383540 ↗IND Pathway / Registered Trials
The investigational pathway and multi-stage clinical-research records, including Phase I/II studies publicly registered on ClinicalTrials.gov.
ClinicalTrials.gov / NCT02745184 ↗U.S. FDA Orphan Drug Designation
Regend Therapeutics Co., Ltd.’s autologous cell product derived from human airway basal cells received U.S. FDA orphan-drug designation for IPF on February 4, 2025. This is not marketing approval.
FDA ODD official record ↗powered by tiptop → CELLshot
tiptop translates public science into original ingredients, freeze-drying, packaging, quality review and manufacturing in Japan. CELLshot brings that technical path into daily skin rituals.
tiptop Source Index ↗Medical research, clinical-trial registrations and FDA designations are scientific and regulatory background. They do not imply therapeutic effects, approval or guaranteed efficacy for CELLshot cosmetics.
Concept film; not actual microscopic imagery.
FORMULATION DESIGN
Freeze-dried
Mixed immediately before use
Powder and liquid remain separate during storage, then become one at the moment of use. CELLshot’s two lead products bring this philosophy into daily care through different packaging structures.
1 membrane + 3 essences01ExoMask Pro
Biomembrane Infusion
Biomembrane Infusion
Dual chamber02ExoSerum Pro
Dual-Chamber Flash Release
Dual-Chamber Flash Release
ORIGINAL INGREDIENT / REGISTRATION IDENTITY
Original ingredient identity and registration
A human endometrial stem-cell-derived extracellular-vesicle ingredient originally developed by tiptop and carried through international and Japanese cosmetic nomenclature registration.
INCI NAMEHuman Endometrial Stem Cell ExosomesMONO ID 39001
JCIA NAMEヒト子宮内膜幹細胞エクソソーム受付番号 22787
ATDS
ATDS organizes ingredients, delivery design, quality review and disclosure within tiptop’s Anti-aging Targeted Delivery Standards.
Explore ATDS on tiptop →tiptop Source Index
A public index of DOI, PubMed, ingredient names, registrations and test reports, organized so that each source and meaning remains clear.
Review the public sources →
POWERED BY tiptop / TECHNOLOGY PLATFORM
Original ingredientsPrecision-made skincare
tiptop connects global scientific insight, original ingredient development, international nomenclature, quality design and precision manufacturing in Japan. Powered by tiptop, CELLshot translates that capability into skincare made for real rituals.
Explore the tiptop technology platform